UpToDate
Official reprint from UpToDate®
www.uptodate.com ©2017 UpToDate, Inc. and/or its affiliates. All Rights Reserved.

Medline ® Abstract for Reference 132

of 'Risk factors for and possible causes of osteoarthritis'

132
TI
Tissue calcification and inflammation in osteoarthritis.
AU
Doyle DV
SO
J Pathol. 1982;136(3):199.
 
Clinical evidence of inflammation and the presence of calcium phosphate crystals in the joint fluid are both characteristics frequently seen in osteoarthritic patients. However, the relevance of the crystal deposition to the pathogenesis of osteoarthritis remains unclear. In this study of 28 patients with advanced osteoarthritis the frequency and type of crystal deposition has been investigated and the relationship between tissue inflammation and crystal deposition has been explored. Tissue calcification, though present in all patients, is but one of several intra-articular inflammatory agents. Its relevance to inflammation in osteoarthritis is discussed.
AD
PMID