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Medline ® Abstract for Reference 122

of 'Risk factors for and possible causes of osteoarthritis'

Localisation of a gene for chondrocalcinosis to chromosome 5p.
Hughes AE, McGibbon D, Woodward E, Dixey J, Doherty M
Hum Mol Genet. 1995;4(7):1225.
Chondrocalcinosis is a common disorder which may associate with acute and chronic arthritis. A familial form, inherited as an autosomal dominant trait, has been mapped in a large family in which affected members also suffer recurrent fits in childhood. The gene which causes this disease shows linkage with several polymorphic markers on chromosome 5p with a maximum multipoint lod score of 4.6 between D5S810 and D5S416. Mapping a locus for chondrocalcinosis will allow the heterogeneity of the disorder to be assessed and may also be relevant to understanding the aetiology of osteoarthritis with which it commonly associates.
Department of Medical Genetics, Queen's University of Belfast, UK.