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Rising serum PSA following local therapy for prostate cancer: Diagnostic evaluation

Judd W Moul, MD, FACS
W Robert Lee, MD, MS, MEd
Section Editors
Nicholas Vogelzang, MD
Jerome P Richie, MD, FACS
Deputy Editor
Michael E Ross, MD


Prostate specific antigen (PSA) is a sensitive and specific serum marker for prostate tissue. Serial measurements are routinely obtained to detect early disease recurrence in men who have received definitive treatment for localized disease.

Monitoring serum PSA after treatment of localized stage prostate cancer frequently leads to the identification of men with a PSA-only (biochemical) recurrence. Such recurrences generally are identified before there are signs or symptoms of either locoregional recurrence or distant metastases. (See "Follow-up surveillance during and after treatment for prostate cancer".)

The rationale and role of diagnostic studies in patients with a rising serum PSA after definitive treatment for prostate cancer is discussed here. Other relevant topics include:

(See "Rising serum PSA following local therapy for prostate cancer: Definition, natural history, and risk stratification".)

(See "Rising serum PSA after radiation therapy for localized prostate cancer: Salvage local therapy".)


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Literature review current through: Sep 2016. | This topic last updated: Apr 11, 2016.
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