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Rehabilitation after cardiac transplantation

Ileana L Piña, MD, MPH
Section Editor
Sharon A Hunt, MD
Deputy Editor
Susan B Yeon, MD, JD, FACC


In spite of dramatic advances in the survival of cardiac transplant recipients, published reports have consistently shown abnormal levels of functional capacity. Although there is a rapid rise in exercise capacity that occurs at approximately two months post-transplant [1], and many patients return to their normal activities with improved quality of life, exercise function remains 30 to 40 percent below normal [2,3].

Prior studies describing persistently abnormal exercise capacity in the early post-transplant period suggested several possible explanations, including [4]:

Marked deconditioning prior to transplant due to heart failure or due to extended mechanical assistance with a left ventricular assist device. (See "Skeletal muscle dysfunction and exercise intolerance in heart failure" and "Intermediate- and long-term mechanical circulatory support" and "Practical management of long-term mechanical circulatory support devices".)

Surgical denervation of the heart [5]

Corticosteroid therapy-related myopathy (see "Glucocorticoid-induced myopathy")


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Literature review current through: Sep 2016. | This topic last updated: Feb 16, 2016.
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