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Medline ® Abstract for Reference 145

of 'Regulation of iron balance'

Hepcidin in the diagnosis of iron disorders.
Girelli D, Nemeth E, Swinkels DW
Blood. 2016 Jun;127(23):2809-13. Epub 2016 Apr 4.
The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.
Section of Internal Medicine, Department of Medicine, University of Verona, Veneto Region Referral Center for Iron Metabolism Disorders, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy;