The regulation of iron metabolism involves the interaction of a number of specific proteins as well as the interplay between iron absorption, recycling, and iron loss. This topic review will discuss these factors . Disorders of iron balance, both iron deficiency and iron overload, are discussed separately.
ROLE OF SPECIFIC PROTEINS
Our current understanding of iron metabolism and the hallmarks of iron deficiency and excess is based upon the biology of a number of critical proteins including, but not limited to, the following [2-5]:
●Transferrin receptor (TfR)