Recurrence of C3 glomerulopathies after transplantation
- Anuja Java, MD
Anuja Java, MD
- Instructor in Medicine
- Washington University School of Medicine
- Daniel C Brennan, MD, FACP
Daniel C Brennan, MD, FACP
- Editor-in-Chief — Nephrology
- Section Editor — Renal Transplantation
- Professor of Medicine
- Medical Director and Co-Director of the Comprehensive Transplant Center, Department of Internal Medicine, Division of Nephrology
- Johns Hopkins Medical School
Membranoproliferative glomerulonephritis (MPGN, also called mesangiocapillary or lobular glomerulonephritis) is a disease defined by a pattern of glomerular injury observed by light microscopy on renal biopsy.
An MPGN pattern of injury may result from multiple causes including infection, autoimmune diseases, monoclonal gammopathies, and complement dysregulation. MPGN resulting from complement dysregulation is called C3 glomerulopathy.
Patients with C3 glomerulopathy commonly progress to end-stage renal disease (ESRD) and require renal replacement therapy, including dialysis and/or transplantation. Among such patients who undergo transplantation, recurrence is common in the transplanted kidney.
This topic reviews recurrent C3 glomerulopathy in the transplanted kidney. The recurrence in the transplanted kidney of idiopathic MPGN is discussed elsewhere. (See "Recurrence of idiopathic immune complex-mediated membranoproliferative glomerulonephritis (MPGN) after transplantation".)
The presentation, classification, causes, and treatment of MPGN in the native kidney are discussed elsewhere. (See "Clinical presentation, classification, and causes of membranoproliferative glomerulonephritis" and "Evaluation and treatment of membranoproliferative glomerulonephritis" and "C3 glomerulopathies: Dense deposit disease and C3 glomerulonephritis".)
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