Medline ® Abstract for Reference 44
of 'Rapid eye movement sleep behavior disorder'
44
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Rapid Eye Movement Sleep Behavior Disorder in Paraneoplastic Cerebellar Degeneration: Improvement with Immunotherapy.
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Vale TC, Fernandes do Prado LB, do Prado GF, Povoas Barsottini OG, Pedroso JL
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Sleep. 2016;39(1):117-20. Epub 2015 8 31.
STUDY OBJECTIVES:
To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy.
METHODS:
The two patients were evaluated through clinical scale and polysomnography before and after therapy with intravenous immunoglobulin.
RESULTS:
RBD was successfully treated with immunotherapy in both patients. Score on the RBD screening questionnaire dropped from 10 to 1 or 0, allied with the normalization of polysomnographic findings.
CONCLUSIONS:
A marked improvement in RBD after immunotherapy in PCD raises the hypothesis that secondary RBD may be an immune-mediated sleep disorder.
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Movement Disorders Unit, Neurology Service, University Hospital. Department of Internal Medicine, Faculty of Medicine, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Minas Gerais, Brazil.
PMID