Medline ® Abstract for Reference 27
of 'Rapid drug desensitization for immediate hypersensitivity reactions'
Penicillin skin testing in pregnant women with a history of penicillin allergy and group B streptococcus colonization.
Ann Allergy Asthma Immunol. 2006;97(2):164.
BACKGROUND: The safety and utility of penicillin skin testing (PST) in pregnant women with a history of penicillin allergy and group B streptococcus (GBS) colonization have not been studied.
OBJECTIVE: To document the safety and utility of PST in pregnant women with a history of penicillin allergy and GBS colonization.
METHODS: Pregnant GBS culture-positive women with a history compatible with an IgE-mediated or unknown reaction to a penicillin-class antibiotic were recruited for PST. If PST results were negative, penicillin-class antibiotics were recommended for GBS prophylaxis. Adverse reactions associated with PST or antibiotic use from the time of PST through delivery and 6 months post partum were reported.
RESULTS: In 56 enrolled patients, there were only 2 mild adverse reactions (4%) associated with PST and 3 positive PST results (5%). Of the 53 PST-negative patients, 47 (89%) received at least 1 course of penicillin. There were 2 delayed-onset rashes associated with the use of intrapartum penicillins and 1 immediate-onset rash with intrapartum vancomycin therapy in a PST-positive woman. There were 7 reactions (6%) associated with 122 antibiotic courses administered.
CONCLUSIONS: Penicillin skin testing can be performed safelyin pregnant women and, if the results are negative, allows penicillins to be used safely at delivery for GBS prophylaxis.
Department of Allergy, Kaiser Permanente Southern California, San Diego Medical Center, USA.