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Psoralen plus ultraviolet A (PUVA) photochemotherapy

Authors
Elisabeth G Richard, MD
Warwick Morison, MD
Section Editor
Craig A Elmets, MD
Deputy Editor
Rosamaria Corona, MD, DSc

INTRODUCTION

Psoralen plus ultraviolet A (PUVA) photochemotherapy combines the administration of psoralens, a class of phototoxic plant-derived compounds, with an exposure to ultraviolet A radiation (UVA). PUVA is used for the treatment of a variety of skin diseases, including psoriasis, mycosis fungoides, eczema, vitiligo, and graft-versus-host disease [1-3].

This topic will discuss the mechanism of action, treatment protocols, contraindications, adverse effects, and clinical indications of PUVA therapy. The use of PUVA for the treatment of specific skin conditions is discussed separately. UVB phototherapy and UVA1 phototherapy are discussed separately.

(See "Treatment of psoriasis", section on 'Ultraviolet light'.)

(See "Treatment of early stage (IA to IIA) mycosis fungoides", section on 'PUVA'.)

(See "Management of severe refractory atopic dermatitis (eczema)", section on 'Psoralen plus UVA'.)

                          

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Literature review current through: Nov 2016. | This topic last updated: Sat Jul 25 00:00:00 GMT+00:00 2015.
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