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Protein S deficiency

Kenneth A Bauer, MD
Section Editors
Lawrence LK Leung, MD
Donald H Mahoney, Jr, MD
Deputy Editor
Jennifer S Tirnauer, MD


Protein S deficiency is an inherited thrombophilia associated with an increased risk of thromboembolism. Establishing a diagnosis of hereditary protein S deficiency may be difficult, particularly in the setting of an acute thrombosis or anticoagulant administration.

This topic review discusses the diagnosis and management of protein S deficiency.

Separate topic reviews address the appropriate use of thrombophilia testing in various clinical settings:

Children – (See "Screening for inherited thrombophilia in children".)

Patients with venous thromboembolism – (See "Evaluating patients with established venous thromboembolism for acquired and inherited risk factors".)


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Literature review current through: Jun 2016. | This topic last updated: Jul 11, 2016.
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