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Prophylaxis of invasive fungal infections in adult hematopoietic cell transplant recipients

John R Wingard, MD
Section Editor
Kieren A Marr, MD
Deputy Editor
Anna R Thorner, MD


Invasive fungal infections are common in selected hematopoietic cell transplant (HCT) recipients, such as allogeneic HCT recipients during the preengraftment period and in those with severe graft-versus-host disease, and cause substantial morbidity and mortality.

Interest in antifungal prophylaxis for high-risk HCT recipients has been prompted by the rising incidence of life-threatening invasive fungal infections in such patients, the difficulty in establishing the diagnosis early in the course of infection, and the recognition that treatment outcomes are poor if initiation of therapy is delayed.

The epidemiology and prophylaxis of invasive fungal infections in HCT recipients will be discussed here. The epidemiology and prophylaxis of invasive fungal infections in patients with hematologic malignancies is reviewed elsewhere. (See "Prophylaxis of invasive fungal infections in adults with hematologic malignancies".)

Other important issues related to infections in HCT recipients are discussed separately:

(See "Evaluation for infection before hematopoietic cell transplantation".)


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Literature review current through: Sep 2016. | This topic last updated: Jul 27, 2016.
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