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Medline ® Abstract for Reference 68

of 'Prognostic and predictive factors in early, nonmetastatic breast cancer'

Estimation of epidermal growth factor receptor in 177 breast cancers: correlation with prognostic factors.
Bolla M, Chedin M, Souvignet C, Marron J, Arnould C, Chambaz E
Breast Cancer Res Treat. 1990;16(2):97.
Steroid receptors (ER, PR) and EGF-receptor were determined on 177 loco-regional primary breast cancers. Binding assay for EGF receptor was performed using a single saturating concentration of 125I-EGF incubated with membranes in the presence or absence of unlabeled EGF. With threshold values of 5 fmol/mg and 10 fmol/mg for EGF-R and steroid receptors respectively, we noted an inverse relationship between the expression of EGF-R, and ER and PR. EGF-R expression is decreased with tumor differentiation.
Radiotherapy Department, Centre Hospitalo-Universitaire Albert Michallon, Grenoble, France.