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Medline ® Abstract for Reference 42

of 'Prognostic and predictive factors in early, nonmetastatic breast cancer'

42
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Breast cancer survival in relation to the metastatic tumor burden in axillary lymph nodes.
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Andersson Y, Frisell J, Sylvan M, de Boniface J, Bergkvist L
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J Clin Oncol. 2010 Jun;28(17):2868-73. Epub 2010 May 10.
 
PURPOSE: The aim of this study was to determine the prognostic significance of lymph node micrometastases in patients with breast cancer.
PATIENTS AND METHODS: Between September 2000 and January 2004, 3,369 patients with breast cancer were included in a prospective cohort. According to their lymph node status, they were classified in the following four groups: 2,383 were node negative, 107 had isolated tumor cells, 123 had micrometastases, and 756 had macrometastases. Median follow-up time was 52 months. Kaplan-Meier estimates and the multivariate Cox proportional hazard regression model were used to analyze survival.
RESULTS: Five-year cause-specific and event-free survival rates were lower for patients with micrometastases (pN1mi) than for node-negative (pN0) patients (94.1% v 96.9% and 79.6% v 87.1%, respectively; P = .020 and P = .032, respectively). There was no significant survival difference between node-negative patients and those with isolated tumor cells. The overall survival of pN1mi and pN0 patients did not differ.
CONCLUSION: This study demonstrates a worse prognosis for patients with micrometastases than for node-negative patients.
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Department of Surgery, Central Hospital, SE-72189 Västerås, Sweden. yvette.andersson@ltv.se
PMID