Prognosis of diffuse large B cell lymphoma
- Arnold S Freedman, MD
Arnold S Freedman, MD
- Section Editor — Lymphoproliferative Disorders
- Professor of Medicine
- Harvard Medical School
- Jon C Aster, MD
Jon C Aster, MD
- Professor of Pathology
- Harvard Medical School
Diffuse large B cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma (NHL) accounting for approximately 25 percent of NHL cases [1,2]. (See "Classification of the hematopoietic neoplasms".)
It is increasingly appreciated that the diagnostic category of "DLBCL" is quite heterogeneous in terms of morphology, genetics, and biologic behavior. A number of clinicopathologic entities are now recognized that are sufficiently distinct to be considered separate diagnostic categories:
●T cell histiocyte rich large B cell lymphoma. (See "Epidemiology, clinical manifestations, pathologic features, and diagnosis of diffuse large B cell lymphoma", section on 'T cell histiocyte rich large B cell lymphoma'.)
●Primary DLBCL of the mediastinum, also called primary mediastinal large B cell lymphoma. (See "Primary mediastinal large B cell lymphoma".)
●Intravascular lymphoma. (See "Intravascular large cell lymphoma".)
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- INTERNATIONAL PROGNOSTIC INDEX
- Original IPI
- - Use of IPI for patients receiving rituximab
- - Age-adjusted IPI
- - Stage-adjusted IPI
- MOLECULAR GENETICS
- Cell of origin studies
- - Gene expression profiling
- - Hans and Tally methods
- - Lymph2Cx platform
- Double hit and double expressor DLBCL
- - "Double-hit" lymphoma
- - "Double expressor" lymphoma
- Identifying molecular subtype
- Deep sequencing of DLBCL genomes
- Sequencing of free DNA in plasma