Prognosis and treatment of mixed connective tissue disease
- Robert M Bennett, MD, FRCP, MACR
Robert M Bennett, MD, FRCP, MACR
- Professor of Medicine
- Oregon Health & Science University
Mixed connective tissue disease (MCTD) is a generalized connective tissue disorder that includes clinical features commonly seen in systemic lupus erythematosus (SLE), scleroderma, and polymyositis (referred to as overlap syndrome) (table 1) . Almost any organ system can be involved in MCTD. There are, however, several clinical features that, taken together, suggest the presence of MCTD rather than another connective tissue disorder:
●Raynaud phenomenon and swollen hands or puffy fingers
●A high titer speckled pattern antinuclear antibody (ANA) (usually ≥1280)
●The absence of severe renal and central nervous system (CNS) disease
●More severe arthritis, which is sometimes deforming
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