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Medline ® Abstract for Reference 7

of 'Principles of cancer immunotherapy'

Mechanisms for T cell receptor triggering.
van der Merwe PA, Dushek O
Nat Rev Immunol. 2011 Jan;11(1):47-55. Epub 2010 Dec 03.
There is considerable controversy about the mechanism of T cell receptor (TCR) triggering, the process by which the TCR tranduces signals across the plasma membrane after binding to its ligand (an agonist peptide complexed with an MHC molecule). Three main types of mechanism have been proposed, which involve aggregation, conformational change and segregation. Here, we review recently published evidence for each type of mechanism and conclude that all three may be involved. This complexity may reflect the uniquely demanding nature of TCR-mediated antigen recognition, which requires the detection of a very weak 'signal' (very rare foreign peptide-MHC ligands) in the presence of considerable 'noise' (abundant self peptide-MHC molecules).
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. anton.vandermerwe@path.ox.ac.uk