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Medline ® Abstract for Reference 60

of 'Principles of cancer immunotherapy'

Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells.
Kisielow M, Kisielow J, Capoferri-Sollami G, Karjalainen K
Eur J Immunol. 2005 Jul;35(7):2081-8.
Lymphocyte activation gene 3 (LAG-3/CD223) is a CD4 homolog known to be selectively expressed in activated T and NK cells. It is thought to have a negative regulatory function in T cells. With the help of new monoclonal antibodies against mouse LAG-3, we show that LAG-3 surface expression is not limited to activated T and NK cells but is also found on activated B cells. Induction of B cell surface expression is T cell dependent and mediated by a soluble factor. The majority of LAG-3 on B cell surface is endogenously produced, even though soluble LAG-3 is present in the culture supernatants and can be passively absorbed. As B cells express LAG-3 in a T cell dependent manner and not when activated by Toll-like-receptor agonists alone, we propose LAG-3 as a new marker of T cell induced B cell activation.
Institute for Research in Biomedicine, Bellinzona, Switzerland.