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Primary percutaneous coronary intervention in acute ST-elevation myocardial infarction: Non-culprit lesions

J Dawn Abbott, MD, FACC
Paul Sorajja, MD
Section Editor
Donald Cutlip, MD
Deputy Editor
Gordon M Saperia, MD, FACC


Coronary artery reperfusion with primary percutaneous coronary intervention, compared with either no reperfusion therapy or fibrinolysis, improves outcomes in patients with acute ST-elevation myocardial infarction (STEMI) if performed in a timely fashion. (See "Acute ST elevation myocardial infarction: Selecting a reperfusion strategy", section on 'Summary and recommendations'.)

Usually, the lesion responsible for the infarct, often referred to as the “culprit lesion,” is readily identified and an attempt is made to re-establish blood flow with the use of thrombectomy, balloon angioplasty, or placement of one or more stents. (See "Primary percutaneous coronary intervention in acute ST elevation myocardial infarction: Periprocedural management".)

In addition to the culprit lesion(s), about 50 percent of STEMI patients have one or more obstructive lesions remote from the area of infarction (ie, “non-culprit” lesions). This topic will address the management of non-culprit lesions in patients with STEMI.


For patients with ST-elevation myocardial infarction who have been referred for primary percutaneous coronary intervention (PCI) and who have had non-culprit lesions identified, we use the following sequential approach:

We perform primary PCI of the culprit lesion.


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Literature review current through: Sep 2016. | This topic last updated: Oct 10, 2016.
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