Primary cutaneous large B cell lymphoma, leg type
- Eric Jacobsen, MD
Eric Jacobsen, MD
- Assistant Professor of Medicine
- Harvard Medical School
- Arnold S Freedman, MD
Arnold S Freedman, MD
- Section Editor — Lymphoproliferative Disorders
- Professor of Medicine
- Harvard Medical School
- Rein Willemze, MD
Rein Willemze, MD
- Professor and Chairman, Department of Dermatology
- Leiden University Medical Center
- Section Editors
- Timothy Michael Kuzel, MD, FACP
Timothy Michael Kuzel, MD, FACP
- Section Editor — Lymphoproliferative Disorders
- Professor of Medicine, Rush University Medical Center
- Chief, Division of Hematology/Oncology/Cell Therapy
- John A Zic, MD
John A Zic, MD
- Section Editor — Cutaneous Lymphoma
- Associate Professor of Medicine/Dermatology
- Vanderbilt University School of Medicine
Primary cutaneous B cell lymphoma (PCBCL) refers to those cases of B cell lymphoma that present in the skin when there is no evidence of extracutaneous disease at the time of diagnosis and after the completion of an initial staging evaluation. There are three main subtypes of PCBCL:
●Primary cutaneous follicle center lymphoma (PCFCL)
●Primary cutaneous large B cell lymphoma (PCLBCL), leg type
●Primary cutaneous marginal zone lymphoma (PCMZL), included in the broader category of extranodal marginal zone B cell lymphoma
These appear to be unique entities with differing clinical presentation, pathologic features, prognosis, and treatment approach. This topic review will discuss primary cutaneous large B cell lymphoma; leg type.
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- CLINICAL FEATURES
- PATHOLOGIC FEATURES
- DIFFERENTIAL DIAGNOSIS
- Systemic lymphoma
- Primary cutaneous follicle center lymphoma
- Primary cutaneous marginal zone lymphoma
- Cutaneous T cell lymphoma
- Intravascular lymphoma
- Iatrogenic immunodeficiency-associated lymphoproliferative disorders
- ASSESSING DISEASE RESPONSE
- TREATMENT AT RELAPSE
- SUMMARY AND RECOMMENDATIONS