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Prevention of active cytomegalovirus infection and disease in kidney transplant recipients

Authors
Carlos AQ Santos, MD, MPHS
John Vella, MD, FACP, FRCP, FASN
Daniel C Brennan, MD, FACP
Section Editors
Barbara Murphy, MB, BAO, BCh, FRCPI
Kieren A Marr, MD
Deputy Editors
Albert Q Lam, MD
Anna R Thorner, MD

INTRODUCTION

Cytomegalovirus (CMV) is a globally widespread virus that becomes latent following primary infection but reactivates frequently and, in the setting of immunocompromise, causes disease in solid organ transplant patients, including kidney transplant recipients [1]. After kidney transplantation, active CMV infection and disease are associated with increased risk of allograft failure and death; thus, CMV prevention strategies are commonly used in such patients. Preventive therapy decreases reactivation in the setting of latent infection in the transplant recipient and/or acquisition of acute infection in CMV-seronegative recipients of seropositive grafts. However, CMV disease may still occur despite preventive therapies, especially when they are not dosed adequately [2,3]. It also occurs following discontinuation of preventive therapy.

This topic reviews the risk factors, clinical significance, and prevention of CMV infection among kidney transplant recipients. The management of active CMV infection and disease in transplant recipients is discussed elsewhere. (See "Clinical manifestations, diagnosis, and management of cytomegalovirus disease in kidney transplant recipients".)

The diagnosis of CMV infection and the epidemiology, clinical manifestations, and treatment of CMV infection immunocompetent adults are also discussed elsewhere. (See "Overview of diagnostic tests for cytomegalovirus infection" and "Approach to the diagnosis of cytomegalovirus infection" and "Epidemiology, clinical manifestations, and treatment of cytomegalovirus infection in immunocompetent adults".)

DEFINITIONS

Like other members of the Herpesvirus family, CMV establishes latent infection after the resolution of acute (or primary) infection. Patients who are CMV seropositive have latent infection. Secondary, symptomatic disease may present later, reflecting either reactivation of latent CMV or, less commonly, reinfection with a novel exogenous strain. The risk of CMV reactivation is highest in the setting of systemic immunosuppression.

CMV can present in kidney transplant recipients as either CMV infection or CMV disease [1,4,5].

          

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Literature review current through: Nov 2016. | This topic last updated: Wed Jun 29 00:00:00 GMT+00:00 2016.
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References
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