Medline ® Abstract for Reference 114
of 'Prevention and treatment of chemotherapy-induced nausea and vomiting in adults'
The use of ondansetron in patients receiving multiple-day cisplatin regimens.
Semin Oncol. 1992;19(4 Suppl 10):48.
The control of nausea and vomiting in patients receiving multiple-day cisplatin chemotherapy has remained difficult, even with the use of combination antiemetic regimens containing metoclopramide. Although these patients receive a lower daily dose of cisplatin, the emetogenic potential remains high. In addition, many of the patients receiving multiple-day cisplatin regimens are young (eg, testicular cancer patients) and, therefore, have particular problems with the extrapyramidal side effects associated with metoclopramide. Studies show that ondansetron, used as a single antiemetic agent, is effective, safe, and well tolerated in the control of nausea and vomiting in patients receiving multiple-day cisplatin regimens.
Vanderbilt University, Nashville, TN.