Medline ® Abstract for Reference 97
of 'Prevention and management of side effects in patients receiving opioids for chronic pain'
Are we still scratching the surface? A case of intractable pruritus following systemic opioid analgesia.
Tarcatu D, Tamasdan C, Moryl N, Obbens E
J Opioid Manag. 2007;3(3):167.
This article describes a case of severe opioid-induced pruritus following systemic morphine administration. Symptoms did not resolve after administration of antihistamines or rotation to fentanyl or hydromorphone, but oral oxycodone and small-dose intravenous naloxone did alleviate the patient's itching. The pathogenesis of opioid-induced pruritus and the rationale for opioid rotation are briefly discussed. Current and possible future therapeutic options are mentioned.
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.