Official reprint from UpToDate®
www.uptodate.com ©2017 UpToDate, Inc. and/or its affiliates. All Rights Reserved.

Medline ® Abstract for Reference 96

of 'Prevention and management of side effects in patients receiving opioids for chronic pain'

Paroxetine for pruritus in advanced cancer.
Zylicz Z, Smits C, Krajnik M
J Pain Symptom Manage. 1998;16(2):121.
Pruritus associated with malignancy may be one of the most bothersome symptoms in advanced cancer. Its control is still difficult to achieve and is a challenge to palliative medicine specialists. We describe five patients suffering from pruritus of different etiologies who responded rapidly to administration of paroxetine, a serotonin reuptake inhibitor, in a dose-dependent manner. Two patients experienced transient but severe nausea and vomiting. We suggest that paroxetine's antipruritic effect may be explained by rapid downregulation of the 5-HTs receptors, which may have an important role in the generation of pruritus and pain.
Hospice Rozenheuvel, Rozendaal, The Netherlands.