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Medline ® Abstract for Reference 66

of 'Prevention and management of side effects in patients receiving opioids for chronic pain'

Modafinil treatment of opioid-induced sedation.
Webster L, Andrews M, Stoddard G
Pain Med. 2003;4(2):135.
STUDY OBJECTIVE: The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation.
DESIGN: A 1-year retrospective chart review of all patients receiving modafinil, a wake-promoting agent, to treat opioid-induced sedation. Opioid-induced sedation was measured using Epworth Sleepiness Scale (ESS).
SETTING: Outpatient, private practice.
PATIENTS: Eleven adult patients, six female and five male, being treated with opioids for chronic, nonmalignant pain.
RESULTS: A significant decrease was observed between pretreatment and posttreatment ESS measurements during modafinil treatment.
CONCLUSION: The results suggest an improvement in opioid-induced sedation in patients treated for nonmalignant pain.
Alpine Pain and Addiction Medicine, Salt Lake City, Utah 84107, USA. lynnw@alpinemedical.com