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Medline ® Abstract for Reference 55

of 'Prevention and management of side effects in patients receiving opioids for chronic pain'

55
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Pharmacologic treatment of opioid-induced sedation in chronic pain.
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Reissig JE, Rybarczyk AM
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Ann Pharmacother. 2005;39(4):727.
 
OBJECTIVE: To review the literature for pharmacologic management of opioid-induced sedation (OIS) in patients with chronic pain.
DATA SOURCES: A search of MEDLINE (1966-October 2004) for English-language literature and selected bibliographies was completed. Search terms included pain, opioid, sedation, psychostimulants, amphetamines, modafinil, and donepezil.
DATA SYNTHESIS: Amphetamines and amphetamine-like agents, caffeine, donepezil, and modafinil have been evaluated for OIS. Available literature is limited by numbers of subjects, duration, and trial design; however, there is limited support for the use of methylphenidate, donepezil, and modafinil.
CONCLUSIONS: Pharmacologic treatment of OIS should be utilized selectively, given the available literature. Methylphenidate, donepezil, and modafinil may be considered in appropriate patients.
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Pain Management, Akron General Medical Center, Akron, OH 44398-7191, USA. jreissig@agmc.org
PMID