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Medline ® Abstract for Reference 109

of 'Prevention and management of side effects in patients receiving opioids for chronic pain'

109
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Opioid-induced abnormal pain sensitivity.
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Mao J
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Curr Pain Headache Rep. 2006;10(1):67.
 
Opioid analgesics are effective for treating many pain conditions. Opioid analgesic tolerance is a pharmacologic phenomenon that could affect the clinical use of opioid analgesics. Recent studies have shown that neural plasticity associated with the development of opioid tolerance may activate a pronociceptive mechanism that could counteract the analgesic effects of opioids. Thus, exposure to opioids could lead to two seemingly unrelated cellular processes (ie, the development of opioid tolerance and opioid-induced pain sensitivity). Their converging effects may be part of the mechanisms leading to the reduced opioid analgesic efficacy in chronic opioid therapy.
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MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, 02114, USA. jmao@partners.org
PMID