Modafinil treatment of opioid-induced sedation

Pain Med. 2003 Jun;4(2):135-40. doi: 10.1046/j.1526-4637.2003.03014.x.

Abstract

Study objective: The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation.

Design: A 1-year retrospective chart review of all patients receiving modafinil, a wake-promoting agent, to treat opioid-induced sedation. Opioid-induced sedation was measured using Epworth Sleepiness Scale (ESS).

Setting: Outpatient, private practice.

Patients: Eleven adult patients, six female and five male, being treated with opioids for chronic, nonmalignant pain.

Results: A significant decrease was observed between pretreatment and posttreatment ESS measurements during modafinil treatment.

Conclusion: The results suggest an improvement in opioid-induced sedation in patients treated for nonmalignant pain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analgesics, Opioid / adverse effects*
  • Analgesics, Opioid / therapeutic use
  • Benzhydryl Compounds / therapeutic use*
  • Central Nervous System Stimulants / therapeutic use*
  • Disorders of Excessive Somnolence / chemically induced*
  • Female
  • Humans
  • Male
  • Medical Records
  • Middle Aged
  • Modafinil
  • Pain / drug therapy
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Analgesics, Opioid
  • Benzhydryl Compounds
  • Central Nervous System Stimulants
  • Modafinil