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Medline ® Abstract for Reference 93

of 'Prevalence of BRCA1 and BRCA2 mutations and associated cancer risks'

Modifiers of risk of hereditary breast and ovarian cancer.
Narod SA
Nat Rev Cancer. 2002;2(2):113.
Hereditary breast and ovarian cancer is among the most commonly encountered adult genetic disease, and it is increasingly important that geneticists, oncologists, surgeons and gynaecologists are aware of the issues regarding risk assessment, prevention and management of women with inherited susceptibility to cancer. Genetic risk can be modified by external factors, but what are these factors, and how might our knowledge of them help us to better define the risks for individual women and to develop strategies for cancer prevention?
Centre for Research on Women's Health, Women's College Hospital, 790 Bay Street, Room 750, University of Toronto, Toronto, Canada M5G 1N8. steven.narod@swchsc.on.ca