Pretreatment evaluation of adults with systemic sclerosis (scleroderma)
- Christopher P Denton, MD
Christopher P Denton, MD
- Professor of Experimental Rheumatology
- Royal Free Hospital, London
Scleroderma encompasses a spectrum of related disorders, most of which share a characteristic clinical feature of skin thickening due to an excess of collagen-containing extracellular matrix within the dermis.
The classification of scleroderma is presented separately, but a brief summary is included for the purpose of this overview of treatment. The simplest division of the scleroderma-related disorders is into localized and systemic forms of the disease. (See "Overview and classification of scleroderma disorders".)
Localized scleroderma, which is generally termed morphea to avoid confusion with systemic disease, can be divided into (table 1):
●Circumscribed plaque morphea
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