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Pretreatment evaluation of adults with systemic sclerosis (scleroderma)

Christopher P Denton, MD
Section Editor
John S Axford, DSc, MD, FRCP, FRCPCH
Deputy Editor
Monica Ramirez Curtis, MD, MPH


Scleroderma encompasses a spectrum of related disorders, most of which share a characteristic clinical feature of skin thickening due to an excess of collagen-containing extracellular matrix within the dermis.

The classification of scleroderma is presented separately, but a brief summary is included for the purpose of this overview of treatment. The simplest division of the scleroderma-related disorders is into localized and systemic forms of the disease. (See "Overview and classification of scleroderma disorders".)

Localized scleroderma, which is generally termed morphea to avoid confusion with systemic disease, can be divided into (table 1):

Circumscribed plaque morphea

Generalized morphea


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Literature review current through: Sep 2016. | This topic last updated: May 31, 2016.
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