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Pretreatment evaluation and prognosis of acute myeloid leukemia in older adults

Richard A Larson, MD
Heidi D Klepin, MD, MS
Section Editor
Bob Lowenberg, MD, PhD
Deputy Editor
Alan G Rosmarin, MD


Among patients with acute myeloid leukemia (AML), treatment regimens and outcomes may differ among younger and older adults. Although there is no clear dividing line when considering age in AML, in most studies "older adults" was defined as over age 60.

The management of older patients with AML is a difficult challenge [1]. Older adults are more likely to have impaired functional status and comorbidities that can limit treatment options; the disease also tends to be more aggressive biologically; thus, outcomes are considerably worse than in younger patients.

This topic review will discuss the pretreatment evaluation and prognosis of older adults with AML. The following topics are presented separately:

The treatment of older adults with AML (see "Treatment of acute myeloid leukemia in older adults")

The treatment of adults of any age with acute promyelocytic leukemia (FAB M3 AML) (see "Initial treatment of acute promyelocytic leukemia in adults")


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Literature review current through: Sep 2016. | This topic last updated: Apr 6, 2015.
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