Presentation, initial evaluation, and prognosis of malignant pleural mesothelioma
- Daniel H Sterman, MD
Daniel H Sterman, MD
- Director, Division of Pulmonary, Critical Care, and Sleep Medicine
- NYU School of Medicine
- NYU Langone Medical Center
- Leslie A Litzky, MD
Leslie A Litzky, MD
- Professor of Pathology and Laboratory Medicine
- University of Pennsylvania Medical Center
- Larry R Kaiser, MD
Larry R Kaiser, MD
- President and CEO, Temple University Health System
- Sr. Executive Vice President for Health Sciences, Temple University
- Dean, Temple University School of Medicine
- Section Editors
- Rogerio C Lilenbaum, MD, FACP
Rogerio C Lilenbaum, MD, FACP
- Section Editor — Lung Cancer
- Yale Cancer Center
- Eric Vallières, MD, FRCSC
Eric Vallières, MD, FRCSC
- Surgical Director of the Lung Cancer Program
- Swedish Cancer Institute
Malignant mesothelioma is a rare and insidious neoplasm with a poor prognosis. It arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or pericardium. Malignant pleural mesothelioma (MPM) is the most common type and can be difficult to treat because most patients have advanced disease at presentation.
The clinical presentation, evaluation, staging, and prognosis of MPM will be reviewed here. Epidemiology and treatment of pleural mesothelioma, as well as issues related to peritoneal mesothelioma are covered elsewhere:
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- CLINICAL MANIFESTATIONS
- Physical exam findings
- Findings on imaging
- Tissue diagnosis
- DIFFERENTIAL DIAGNOSIS
- STAGING AND PRETREATMENT EVALUATION
- Staging systems
- Staging evaluation
- - Advanced imaging
- - Surgical staging
- Pretreatment evaluation
- Prognostic factors
- Prognostic scoring systems
- BIOMARKERS UNDER INVESTIGATION
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS