Preparation of blood components
- Arthur J Silvergleid, MD
Arthur J Silvergleid, MD
- Section Editor — Transfusion Medicine
- Affiliate Associate Professor, Department of Pathology and Cell Biology
- University of South Florida, College of Medicine
- Medical Director, OneBlood, Inc.
Blood components are those products derived from whole blood (or platelet-rich plasma) collected from normal donors by phlebotomy (or hemapheresis) using the technique of differential centrifugation. These products are prepared in blood centers or hospital laboratories, and should be distinguished from plasma derivatives, which are fractionated from large volumes (thousands of liters) of plasma in large, industrial manufacturing sites.
This topic review will discuss the preparation of blood components.
Use of these blood components is discussed separately.
●Plasma – (See "Clinical use of plasma components".)
●Red blood cells – (See "Red blood cell transfusion in adults: Storage, specialized modifications, and infusion parameters" and "Red blood cell transfusions in the newborn" and "Red blood cell transfusion in infants and children: Selection of blood products" and "Indications and hemoglobin thresholds for red blood cell transfusion in the adult".)
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- Slichter SJ, Raife TJ, Davis K, et al. Platelets photochemically treated with amotosalen HCl and ultraviolet A light correct prolonged bleeding times in patients with thrombocytopenia. Transfusion 2006; 46:731.
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- Vamvakas EC. Meta-analysis of the randomized controlled trials of the hemostatic efficacy and capacity of pathogen-reduced platelets. Transfusion 2011; 51:1058.
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- GENERAL PRINCIPLES
- Blood donors
- Plasma fractionation
- BLOOD COLLECTION
- ANTICOAGULANT/PRESERVATIVE SOLUTIONS
- BLOOD COMPONENTS
- Red cell concentrates
- Platelet concentrates
- - Single donor apheresis platelets
- - Platelets derived from whole blood
- - Leukocyte-reduced platelets
- - Bacterial contamination
- - Pathogen reduction
- Available preparations
- Usage guidelines