Medline ® Abstract for Reference 17
of 'Pregnancy in women with pre-existing chronic liver disease'
17
TI
Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?
AU
Wegmann TG, Lin H, Guilbert L, Mosmann TR
SO
Immunol Today. 1993;14(7):353.
Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since TH1 cytokines compromise pregnancy and TH2 cytokines are produced at the maternal-fetal interface, we hypothesize that these TH2 cytokines inhibit TH1 responses, improving fetal survival but impairing responses against some pathogens.
AD
Dept of Immunology, University of Alberta, Edmonton, Canada.
PMID