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Pouchitis: Epidemiology, clinical manifestations, and diagnosis

INTRODUCTION

Pouchitis is the most frequently observed long-term complication of ileal pouch-anal anastomosis (IPAA) or a continent ileostomy (ie, Koch pouch). This topic will review the epidemiology, pathogenesis, clinical manifestations, and diagnosis of pouchitis. The management of pouchitis is discussed in detail, separately. (See "Pouchitis: Management".)

DEFINITION

Pouchitis is an inflammatory condition of the ileal pouch reservoir of an ileal pouch-anal anastomosis (IPAA).

Classification — Pouchitis has been classified as follows [1]:

Based on the duration of symptoms into acute (≤4 weeks) versus chronic (>4 weeks).

Based on response to antibiotics into antibiotic-responsive versus antibiotic-dependent (ie, requiring ongoing antibiotic therapy to keep disease in remission) versus antibiotic-refractory (ie, not responding to a standard course of antibiotic therapy).

                     

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Literature review current through: Aug 2014. | This topic last updated: Jul 22, 2014.
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