Postoperative radiation therapy in the management of head and neck cancer
- Shruti Jolly, MD
Shruti Jolly, MD
- Assistant Professor
- University of Michigan Health System
- Avraham Eisbruch, MD
Avraham Eisbruch, MD
- Professor and Associate Chair for Clinical Research
- Department of Radiation Oncology
- University of Michigan
- Francis P Worden, MD
Francis P Worden, MD
- Department of Internal Medicine
- Division of Hematology and Oncology
- University of Michigan
- Richard Smith, MD
Richard Smith, MD
- Professor and Vice-Chair, Otorhinolaryngology-Head and Neck Surgery
- Albert Einstein College of Medicine, Montefiore Medical Center
- Section Editors
- Bruce E Brockstein, MD
Bruce E Brockstein, MD
- Section Editor — Cancer of the Head and Neck
- Clinical Professor of Medicine
- University of Chicago Pritzker School of Medicine
- David M Brizel, MD
David M Brizel, MD
- Section Editor — Radiation Therapy
- Leonard R Prosnitz Professor of Radiation Oncology
- Professor of Otolaryngology Head & Neck Surgery
- Duke University Cancer Institute
- Marshall R Posner, MD
Marshall R Posner, MD
- Section Editor — Cancer of the Head and Neck
- Professor of Gene and Cell Medicine
- The Tisch Cancer Institute
- Icahn School of Medicine at Mount Sinai
- Marvin P Fried, MD, FACS
Marvin P Fried, MD, FACS
- Section Editor — Head and Neck Surgery
- Professor and University Chairman, Department of Otorhinolaryngology - Head and Neck Surgery
- Montefiore Medical Center, Albert Einstein College of Medicine
Selected high-risk patients with head and neck squamous cell carcinoma receive postoperative radiation therapy (RT), with or without concurrent chemotherapy, following primary surgical resection with the aim of improving locoregional control and survival. The rationale for this approach is that RT may eradicate microscopic deposits of cancer cells that would progress and lead to a locoregional recurrence.
The role of postoperative RT for head and neck cancer, usually given with concurrent chemotherapy, will be reviewed here. Other relevant topics include:
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- APPROACH TO POSTOPERATIVE MANAGEMENT
- POSTOPERATIVE CHEMORADIATION
- Chemoradiotherapy versus radiotherapy alone
- Concurrent chemotherapy regimen
- - Platinum-based chemotherapy
- - Cetuximab
- - Docetaxel
- POSTOPERATIVE RT ALONE
- Initiation and treatment delays
- Dose and treatment volume
- Radiotherapy techniques
- Postoperative versus preoperative RT
- SUMMARY AND RECOMMENDATIONS