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Possibly effective emerging therapies for heart failure

INTRODUCTION

Symptomatic heart failure (HF), generally defined as New York Heart Association (NYHA) class II to IV, is associated with increased mortality that is due primarily to progression of the myocardial dysfunction (table 1). (See "Prognosis of heart failure".)

Treatment of HF is aimed at three goals: improvement in symptoms, slowing of disease progression, and prolongation of survival [1]:

Improvement in symptoms can be achieved in appropriately selected patients with systolic heart failure by a variety of drugs, including digitalis, diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta blockers, and aldosterone antagonists, as well as by cardiac resynchronization therapy.

Prolongation of patient survival in appropriately selected patients with systolic heart failure has been documented with angiotensin converting enzyme (ACE) inhibitors, beta blockers, aldosterone antagonists, cardiac resynchronization, and implantable cardioverter-defibrillator therapy.

In addition to medical therapy, consideration should be given to possible reversible causes of myocardial dysfunction (eg, coronary revascularization and cessation of alcohol intake).

                          

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Literature review current through: Jul 2014. | This topic last updated: Apr 21, 2014.
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