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Possible prevention and therapy of ischemic acute tubular necrosis

Tushar A Chopra, MD
Mark D Okusa, MD
Section Editor
Paul M Palevsky, MD
Deputy Editor
Alice M Sheridan, MD


Acute kidney injury (AKI) due to ischemic acute tubular necrosis (ATN) typically lasts 7 to 21 days [1], with most patients returning to or near their previous baseline level of renal function as the necrotic tubular cells regenerate.

Possible preventive and therapeutic measures for ischemic ATN will be reviewed here.

The pathogenesis and prognosis of ATN are discussed separately. (See "Renal and patient outcomes after acute tubular necrosis" and "Pathogenesis and etiology of ischemic acute tubular necrosis".)


AKI is characterized by an acute reduction of glomerular filtration rate (GFR) and defined by a rise in the serum creatinine concentration or a decline in urine output that has developed within hours to days (table 1). (See "Definition of acute kidney injury (acute renal failure)".)

AKI is commonly, though not always, caused by ATN, particularly among critically ill hospitalized patients.


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Literature review current through: Dec 2016. | This topic last updated: Thu Jan 12 00:00:00 GMT+00:00 2017.
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