Physiology and classification of shock in children

INTRODUCTION

Shock is a physiologic state characterized by a significant, systemic reduction in tissue perfusion, resulting in decreased tissue oxygen delivery. Although the effects of inadequate tissue perfusion are initially reversible, prolonged oxygen deprivation leads to generalized cellular hypoxia and derangement of critical biochemical processes, including [1,2]:

Cell membrane ion pump dysfunction

Intracellular edema

Leakage of intracellular contents into the extracellular space

Inadequate regulation of intracellular pH

            

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Literature review current through: Nov 2014. | This topic last updated: Dec 17, 2014.
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References
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