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Pharmacotherapy for co-occurring schizophrenia and substance use disorder

E Cabrina Campbell, MD
Stanley N Caroff, MD
Stephan C Mann, MD, DLFAPA
Section Editors
Andrew J Saxon, MD
Stephen Marder, MD
Deputy Editor
Richard Hermann, MD


Schizophrenia and addiction are both chronic disorders with serious complications, consequences, and costs for individuals and society. Both conditions are associated with poor adherence to treatment and poorer outcomes when the co-occurring disorder is present.

Some of the symptoms of schizophrenia overlap with symptoms of intoxication, chronic substance use, or withdrawal from alcohol or other drugs. Family history and the temporal relationship of symptoms can help to distinguish patients with a substance use disorder (SUD) alone from co-occurring schizophrenia and SUD.

Pharmacotherapy of co-occurring schizophrenia and SUD are described here. The epidemiology, pathogenesis, clinical manifestations, course, assessment, diagnosis, and psychosocial interventions for co-occurring schizophrenia and SUD are described separately. The epidemiology, pathogenesis, clinical manifestations, course, assessment, diagnosis and treatment of schizophrenia or SUD individually (not co-occurring) are also discussed separately.

(See "Co-occurring schizophrenia and substance use disorder: Epidemiology, pathogenesis, clinical manifestations, course, assessment and diagnosis".)

(See "Psychosocial interventions for co-occurring schizophrenia and substance use disorder".)

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Literature review current through: Nov 2017. | This topic last updated: May 16, 2016.
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