INTRODUCTION — Pelvic organ prolapse (POP) affects millions of women; approximately 200,000 inpatient surgical procedures for prolapse are performed annually in the United States [1,2]. Eleven to 19 percent of women will undergo surgery for prolapse or incontinence by age 80 to 85 years, and 30 percent of these women will require an additional prolapse repair procedure [3,4].
Women with symptomatic POP experience daily discomfort, as well as interference with sexual function and exercise. Reconstructive surgery for women with prolapse consists of some combination of resuspension of the vaginal apex and anterior and posterior vaginal walls. The choice of a primary surgical procedure for women with POP depends upon a variety of considerations, including the anatomic site of prolapse, presence of urinary or fecal incontinence, health status, and patient preferences.
The process of choosing a surgical procedure for women with POP who have not had a prior prolapse repair will be reviewed here. Evaluation of women with POP, conservative management, and specific repair procedures are discussed separately. (See "An overview of the epidemiology, risk factors, clinical manifestations, and management of pelvic organ prolapse in women" and "Vaginal pessary treatment of prolapse and incontinence" and "Pelvic organ prolapse in women: Surgical repair of apical prolapse (uterine or vaginal vault prolapse)" and "Anterior vaginal wall support abnormalities: Evaluation and treatment" and "Surgical management of posterior vaginal defects" and "Pelvic organ prolapse in women: Obliterative procedures (colpocleisis)".)
CANDIDATES FOR SURGICAL TREATMENT — Candidates for surgical repair of POP are women with symptomatic prolapse who have failed or declined conservative management.
Women with symptomatic prolapse — Reconstructive surgery for POP should be performed only in women who have symptomatic prolapse, with few exceptions. Surgical correction of asymptomatic POP or non-bothersome POP is of uncertain benefit and adds perioperative risks.
POP symptoms include pelvic pressure, sensation of a vaginal bulge, urinary retention, and/or difficult defecation; some women need to reduce the prolapse using a finger in the vagina (also referred to as splinting) to urinate or defecate. Prolapsed vaginal tissue may protrude, leading to chronic discharge and bleeding from ulceration. Such symptoms may interfere with daily activities, sexual function, or exercise. (See "An overview of the epidemiology, risk factors, clinical manifestations, and management of pelvic organ prolapse in women", section on 'Clinical manifestations'.)
Many women have asymptomatic POP; approximately 40 percent of women are found to have stage II or greater prolapse upon routine pelvic examination [5-8]. There is no indication for repair of asymptomatic POP as an isolated procedure.
When women undergo other pelvic procedures (eg, vaginal hysterectomy, stress urinary incontinence [SUI] surgery), some surgeons repair asymptomatic prolapse to prevent the need for subsequent surgery. This practice is based upon the assumption that prolapse will progress. This approach remains unproven and may increase surgical morbidity. Interestingly, the natural history of prolapse does not follow a progressive course in all women. Data suggest that the course is progressive until menopause, after which the degree of prolapse may follow a course of alternating progression and regression [9-11]. On the other hand, in addition to premenopausal status, risk factors for the progression of POP include obesity and hysterectomy [12,13]. (See "An overview of the epidemiology, risk factors, clinical manifestations, and management of pelvic organ prolapse in women", section on 'Risk factors'.)
Given the paucity of data regarding repair of asymptomatic POP, for most women with asymptomatic prolapse who are undergoing other pelvic floor procedures (eg, SUI surgery), we suggest not performing prolapse repair. Prolapse repair for asymptomatic women at the time of other pelvic surgery is a reasonable option in women with risk factors for prolapse progression (eg, concomitant hysterectomy, premenopausal status, obesity).
Combined surgical treatment of POP and SUI is discussed separately. (See "Pelvic organ prolapse and stress urinary incontinence in women: Combined surgical treatment", section on 'SUI with asymptomatic POP'.)
Women who decline or fail conservative therapy — First line management of POP is conservative therapy. The mainstay of nonsurgical treatment for POP is the vaginal pessary. Pessaries are silicone devices that are inserted into the vagina and support the pelvic organs. Pelvic floor muscle exercise is another conservative treatment option. (See "An overview of the epidemiology, risk factors, clinical manifestations, and management of pelvic organ prolapse in women", section on 'Conservative management'.)
Prolapse is typically a chronic problem, and many women ultimately prefer surgery to conservative therapy since successful surgery does not require ongoing maintenance. In the patients who can be fit with a pessary, approximately 40 percent of women discontinue pessary use within one to two years of use. It is difficult to estimate how many women who choose to have a pessary go on to have surgery. (See "Vaginal pessary treatment of prolapse and incontinence", section on 'Treatment of prolapse trials'.)
Women finished with childbearing — Pelvic support may be disrupted during pregnancy, and particularly following a vaginal birth. Most surgeons recommend delaying surgical management of POP until childbearing is complete. Small case studies have reported successful pregnancy after uterine-sparing surgery, but no study has specifically investigated the risk of developing recurrent POP after delivery. Seven pregnancies have been reported with one following vaginal and cesarean delivery [13].
Young or elderly women — Patients at a young age are at higher risk of prolapse recurrence and a lower overall risk from surgery compared to older women (table 1) [14-16]. Thus, younger patients are best treated with procedures with better efficacy (eg, abdominal sacral colpopexy rather than vaginal sacrospinous ligament suspension).
POP repair can be safely performed in many elderly women. In a cohort of 267 patients who were > or = 75 years old, 26 percent of the patients had a significant perioperative complication at the time of surgery for POP. The most common perioperative complication was blood transfusion or significant blood loss, pulmonary edema, and postoperative congestive heart failure; however, the overall perioperative morbidity rate in elderly women who undergo urogynecologic surgery is low. Independent risk factors that were predictive of a patient having a perioperative complication were the length of surgery, coronary artery disease, and peripheral vascular disease [17].
Obese women — Although obesity is a risk factor for new onset and recurrent POP [14,15], obese women appear to have no difference in outcome of surgical correction of apical prolapse compared with non-obese women [18]. Many surgeons feel that obese patients are good candidates for the most durable repair, abdominal sacrocolpopexy. Unfortunately, the open abdominal approach in the obese patient increases the risk usually in the form of wound complications [19].
GENERAL APPROACH TO CHOICE OF PROCEDURE — The choice of a primary procedure for POP includes a variety of factors:
A summary of all major decisions involved in choosing a primary surgical procedure to repair POP is presented in the figure (figure 1).
RECONSTRUCTIVE VERSUS OBLITERATIVE PROCEDURES — The choice of a reconstructive or obliterative procedure depends upon the medical status and sexual function of the patient.
Reconstructive surgery surgically corrects the prolapsed vagina and aims to restore normal anatomy, while obliterative surgery corrects prolapse by removing and/or closing off all or a portion of the vaginal canal (ie, colpocleisis or colpectomy) to reduce the viscera back into the pelvis [20]. Another difference between the two types of procedures is that reconstructive surgery can be performed using a vaginal or abdominal approach, while all obliterative surgeries are performed using the vaginal approach.
Most women with symptomatic POP are treated with a reconstructive procedure. Obliterative procedures are reserved for women who cannot tolerate more extensive surgery or who are not planning future vaginal intercourse. The advantages of obliterative procedures in this population are that such procedures typically have a short operative duration, low risk of perioperative morbidity, and an extremely low risk of prolapse recurrence. The obvious disadvantages are the elimination of the potential for vaginal intercourse, as well as the inability to evaluate the cervix or uterus via a vaginal route (eg, cervical cytology or endometrial biopsy).
Colpocleisis is highly effective with low morbidity for correcting apical prolapse in such women. Colpocleisis does not appear to alter body image and regret after the procedure is uncommon (less than 10 percent). Therefore, an obliterative operation is an option for women who are not candidates for more extensive surgery or are willing to accept the loss of vaginal intercourse.
Obliterative procedures for POP are discussed in detail separately. (See "Pelvic organ prolapse in women: Obliterative procedures (colpocleisis)".)
CONCOMITANT HYSTERECTOMY — Hysterectomy is often performed at the time of POP repair. This practice is dependent upon the surgical technique used for pelvic reconstruction and other potential benefits. On the other hand, there is concern that concomitant hysterectomy may increase the risk of some perioperative complications (eg, mesh erosion) and, additionally, an increasing number of women wish to conserve their uterus as an important component of their body image.
During POP repair, surgeons have generally performed hysterectomy rather than uterine-sparing procedures based upon several assertions:
Potential disadvantages of hysterectomy and the associated pelvic floor dissection are an increased risk of pelvic neuropathy and disruption of natural support structures such as the uterosacral cardinal ligament complex [25].
Uterine sparing procedures correct apical prolapse by attaching the lower uterus or cervix to a support structure. These techniques are not widely used, since they have not been well evaluated and most surgeons have not been trained to perform them.
Advantages of uterine sparing techniques are a shorter operative duration and less blood loss; however, their efficacy is controversial [21,22,26-29]. Two randomized trials in women with stage II or higher POP that compared transvaginal sacrospinous hysteropexy with vaginal hysterectomy (with uterosacral or sacrospinous ligament suspension of the vaginal vault) yielded consistent results: the rate of prolapse recurrence after 9 to 12 months was higher in women who underwent hysteropexy in both trials, but reached statistical significance in one trial (27 versus 3 percent [28]) and not the other (25 versus 13 percent [27]). Operative duration (59 versus 120 minutes in one trial [27]) and blood loss (20 versus 120 mL in one trial [27]) were decreased for sacrospinous hysteropexy compared with vaginal hysterectomy; complication rates were similar for the two groups. Further study is needed to evaluate the efficacy of uterine sparing techniques.
A proposed advantage of uterine sparing surgery is a decreased impact on sexual function; however, this benefit is uncertain. The only study of this issue found no difference in effect on sexual function in women who underwent sacrospinous hysteropexy compared with vaginal hysterectomy [30]. Also, studies of hysterectomy for POP and other indications have generally found no impact on sexual function. (See "Overview of hysterectomy", section on 'Psychosexual issues'.)
Uterine-sparing techniques offer the potential for preserving fertility. There are few data, however, regarding the risk of intrapartum complication and postpartum recurrence of prolapse following these procedures [22,31].
While uterine sparing techniques offer benefits of decreased operative duration and blood loss, their efficacy remains unproven. Given the current data, for women undergoing apical prolapse repair, we suggest performing concomitant hysterectomy rather than uterine preservation. A uterine sparing procedure performed by a surgeon familiar with the necessary techniques is a reasonable alternative for women who strongly prefer to preserve their uterus and are aware of the potential risk of recurrent prolapse and the uncertainty regarding obstetric outcomes.
CONCOMITANT REPAIR OF APICAL AND ANTERIOR OR POSTERIOR PROLAPSE — Reconstructive surgery for POP often involves repair of multiple anatomic sites of prolapse (apical, anterior, and/or posterior). Repair of each prolapse site and how to best perform a combined reconstruction must be considered when choosing an overall surgical approach. The common teaching is that all procedures should be performed using one route (vaginal or abdominal), since it is generally preferred to avoid both abdominal and vaginal incisions. In some instances, however, surgeons may combine the two surgical approaches.
Choice of surgical route is mainly of concern in women who require repair of apical prolapse, since isolated repair of anterior or posterior vaginal wall prolapse is typically performed transvaginally (posterior prolapse can also be repaired endoanally). Repair of apical prolapse abdominally with sacral colpopexy results in a lower rate of recurrence, while transvaginal repair (eg, sacrospinous ligament fixation, uterosacral ligament fixation) has a shorter recovery and less morbidity. The choice of surgical technique for specific anatomic sites of prolapse is discussed separately. (See "Surgical management of posterior vaginal defects", section on 'Surgical approaches' and "Pelvic organ prolapse in women: Surgical repair of apical prolapse (uterine or vaginal vault prolapse)", section on 'Vaginal versus abdominal approach' and "Anterior vaginal wall support abnormalities: Evaluation and treatment".).
Patients with apical prolapse have a high rate of anterior prolapse and a lower rate of posterior prolapse [32]. It is controversial whether repair of apical prolapse is sufficient to support the anterior and posterior vaginal walls or if additional procedures are required to address anterior and/or posterior prolapse. If the vaginal muscularis is well suspended at the apex, many anterior defects (55 percent in one study) [33] and some posterior defects will resolve. On the other hand, correction of anterior or posterior prolapse does not repair apical descent. The approach to concomitant repair of multiple sites of prolapse varies by surgical route and by site of prolapse.
Abdominal route — The abdominal route has been used for the repair of both anterior and posterior prolapse.
Anterior prolapse — Among women undergoing sacral colpopexy who also have symptomatic anterior prolapse, anterior vaginal wall support can be achieved transabdominally either by sacral colpopexy alone or by a combined procedure with paravaginal repair. Data are limited on the efficacy and comparative efficacy of these procedures:
Unfortunately, inter- and intra-examiner reliability of the clinical examination for central, superior, and right and left paravaginal defects is poor [37]. Since it is difficult for examiners to agree on whether a paravaginal defect is present, in our practice, we do not routinely perform paravaginal defect repairs for anterior wall support and feel that a good apical suspension obviates the need for a separate repair of the anterior wall. (See "Pelvic organ prolapse in women: Diagnostic evaluation", section on 'Inspection for paravaginal defects'.)
Posterior prolapse — Repair of posterior vaginal wall prolapse at the time of abdominal surgery can be performed in one of three ways:
In the Colpopexy and Urinary Reduction Efforts (CARE) trial, which evaluated the role of Burch colposuspension in women undergoing sacral colpopexy, 87 of 298 women (29 percent) underwent posterior vaginal wall repair in which colporrhaphy, perineorrhaphy, or sacrocolpoperineopexy was used according to surgeon discretion [39]. Women who did or did not undergo posterior repair had a similar rate of improvement in bowel symptoms, including obstructive symptoms (constipation, incomplete emptying and of pain and/or irritation with defecation); posterior anatomic outcomes were also similar for the two groups.
Observational studies of sacral colpopexy with posterior mesh extension, but without posterior colporrhaphy, have had widely variable results. In two prospective studies, the rate of recurrence of posterior prolapse varied from 8 percent at one year [40] to 57 percent at two years [41].
The decision to perform a posterior colporrhaphy is dependent upon whether the patient has patient’s posterior prolapse-related and/or defecatory symptoms and the degree of prolapse of the posterior wall. In our practice, in patients with posterior wall prolapse, we extend the mesh down the posterior vaginal wall to the lower half of the vagina. When symptoms are bothersome and/or the prolapse of the posterior wall extends to or beyond the hymen, we generally perform a posterior colporrhaphy.
Vaginal route — In women undergoing a transvaginal apical suspension, the optimal management of separately addressing anterior and posterior wall prolapse is unclear. Many surgeons perform a simultaneous anterior or posterior colporrhaphy, while others think that an effective vaginal apical suspension obviates for a separate anterior or posterior procedure.
High rates of anterior wall prolapse have been reported for sacrospinous ligament suspension or uterosacral ligament suspension in combination with anterior colporrhaphy (29 percent), and even higher for anterior colporrhaphy alone (30 to 40 percent) [42]. However, most of these studies used a definition of failure defined as recurrence of stage II or higher; new evidence suggests that this definition is too strict and has been based on expert opinion only and not data. Current evidence supports a definition of success as a patient’s perception of bother, which typically corresponds to prolapse beyond the hymen [43]. Using this definition, most studies investigating the efficacy of anterior colporrhaphy show high success rates and low reoperation rates. (See "Pelvic organ prolapse in women: Surgical repair of apical prolapse (uterine or vaginal vault prolapse)", section on 'Outcome' and "Pelvic organ prolapse in women: Surgical repair of apical prolapse (uterine or vaginal vault prolapse)", section on 'Outcome' and "Anterior vaginal wall support abnormalities: Evaluation and treatment".)
In our practice, when apical prolapse, as well as stage II anterior or posterior vaginal wall prolapse, are present during the preoperative examination, we perform an anterior or posterior colporrhaphy in addition to a transvaginal apical suspension.
CONCOMITANT INCONTINENCE SURGERY
Urinary incontinence — Symptomatic POP often coexists with SUI. Women with symptoms of both POP and SUI are treated with a combined prolapse repair and continence procedure.
Another important patient population consists of women with stage II or higher apical prolapse who remain continent despite loss of anterior vaginal and bladder/urethral support. Unfortunately, 13 to 65 percent of continent women develop symptoms of SUI after surgical correction of prolapse. This likely occurs because the prolapse kinks and obstructs the urethra; this obstruction is alleviated when the prolapse is repaired. This is referred to as "occult" or "potential" stress incontinence.
All women with apical prolapse should have a preoperative evaluation for occult SUI with clinical or urodynamic urinary stress testing with and without reduction of prolapse. However, preoperative prolapse reduction testing does not accurately predict postoperative stress incontinence (approximately 40 percent of women with negative testing will develop postoperative stress incontinence).
For women with stage II or greater POP who are undergoing abdominal sacrocolpopexy, regardless of the results of preoperative testing for occult SUI, high quality data support a concomitant Burch colposuspension rather than sacrocolpopexy alone. While there are fewer data regarding prophylactic surgery for stress incontinence in women undergoing transvaginal apical prolapse repair, it appears such preventive surgery is safe and effective for these women. However, due to the absence of high quality data for this patient population, the results of preoperative testing for occult SUI may impact clinical decision-making. Concomitant surgery for POP and SUI is discussed in detail separately. (See "Pelvic organ prolapse and stress urinary incontinence in women: Combined surgical treatment", section on 'POP with no symptoms of SUI'.)
Anal incontinence — Repair of POP may improve symptoms in women who have bothersome symptoms of both POP and anal incontinence. When POP is the patient's primary complaint, some surgeons choose to repair POP prior to recommending surgery for anal incontinence.
Data are mixed regarding the impact of POP repair, specifically rectocele repair, on anal incontinence [44-47]. A prospective study of 101 women undergoing rectocele repair reported that 63 percent who had anal incontinence preoperatively reported resolution or improvement in these symptoms at one year after surgery [44]. In contrast, in a retrospective series of 231 women who underwent posterior colporrhaphy, the prevalence of fecal incontinence increased postoperatively from 4 to 11 percent, and 19 percent of patients developed incontinence of flatus [45]. Further study is needed to evaluate this issue.
Anal incontinence is discussed in detail separately. (See "Fecal incontinence in adults".)
MESH AUGMENTATION — Surgical mesh use is standard in abdominal sacral colpopexy. The use of surgical mesh for transvaginal POP repair has been introduced with the goal of reducing the risk of recurrent prolapse, but this approach is controversial. At present, potentially higher success rates resulting from the use of some mesh products for the anterior, and possibly the apex, of the vagina are accompanied by a higher complication rate than traditional vaginal surgery.
Use of surgical mesh in pelvic reconstructive surgery is discussed in detail separately. (See "Reconstructive materials in urogynecology: Clinical applications".)
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