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Medline ® Abstract for Reference 97

of 'Pediatric palliative care'

97
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Pilot study: fluvoxamine treatment for depression and anxiety disorders in children and adolescents with cancer.
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Gothelf D, Rubinstein M, Shemesh E, Miller O, Farbstein I, Klein A, Weizman A, Apter A, Yaniv I
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J Am Acad Child Adolesc Psychiatry. 2005;44(12):1258.
 
OBJECTIVE: To evaluate the safety, tolerability, and benefit of fluvoxamine for the treatment of major depressive disorder or anxiety disorders in children and adolescents with cancer.
METHOD: The study was conducted from 2001 to 2004 at a pediatric hematology-oncology center. Fifteen children and adolescents with cancer were treated with fluvoxamine 100 mg/day in an open prospective 8-week trial. Safety and tolerability were evaluated at baseline and at weeks 4 and 8 by blood tests and the Side Effects Checklist. Clinical benefit was assessed with the Clinical Global Impressions-Improvement, the Children's Depression Rating Scale-Revised, and the Pediatric Anxiety Rating Scale.
RESULTS: Fluvoxamine was well tolerated by all subjects. Psychiatric symptoms improved significantly.
CONCLUSIONS: In this open trial, fluvoxamine appeared to be well tolerated and was associated witha promising reduction in the depression and anxiety symptoms of pediatric patients with cancer.
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Feinberg Department of Child Psychiatry, Schneider Children's Medical Center of Israel, Petah Tiqwa, Israel. gothelf@post.tau.ac.il
PMID