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Patient evaluation and selection for antiviral therapy for chronic hepatitis C virus infection

Sanjiv Chopra, MD, MACP
Sanjeev Arora, MD, MACP, FACG
Section Editor
Adrian M Di Bisceglie, MD
Deputy Editor
Allyson Bloom, MD


We are at a major inflection point in our long term effort to control the silent epidemic of chronic hepatitis C virus infection (HCV). With the advent of new medicines, the vast majority of patients with HCV infection who have access to them can be cured with treatment. Newer treatments are of shorter duration, have fewer side effects, and have higher cure rates. The goal of treatment of chronic HCV infection is a sustained virologic response (SVR), defined as absence of virus in the blood 12 weeks after the cessation of treatment. Patients achieving an SVR are considered cured, as studies show that 99 percent of patients who achieve a SVR remain free of detectable virus during long term follow up [1].

This topic will review patient selection for antiviral therapy in the context of the availability of all oral HCV regimens, as well as peginterferon and ribavirin-based regimens. The treatment of acute HCV and detailed information on the use of specific treatment regimens for chronic HCV infection are discussed separately:

(See "Clinical manifestations, diagnosis, and treatment of acute hepatitis C virus infection in adults".)

(See "Treatment regimens for chronic hepatitis C virus genotype 1 infection in adults".)

(See "Treatment regimens for chronic hepatitis C virus genotypes 2 and 3 infection in adults".)

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Literature review current through: Nov 2017. | This topic last updated: Aug 07, 2017.
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