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Medline ® Abstract for Reference 33

of 'Pathophysiology and treatment of edema in patients with the nephrotic syndrome'

33
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A critique of the overfill hypothesis of sodium and water retention in the nephrotic syndrome.
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Schrier RW, Fassett RG
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Kidney Int. 1998;53(5):1111.
 
Recent reviews have claimed that the majority of patients with the nephrotic syndrome have plasma volume expansion (that is, they are overfilled). Here we attempt to re-establish balance to the debate on body fluid volume status in nephrotic patients by: (a) discussing the conflicting literature on plasma volume measurements in the nephrotic syndrome; (b) providing alternate explanations for data purporting to support an overfill hypothesis in the nephrotic syndrome; (c) emphasizing secondary neurohumoral responses that support underfilling at least as frequently as overfilling; and (d) emphasizing the clinical importance of fluid assessment in the individual patient with the nephrotic syndrome particularly in relation to diuretic use.
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Department of Medicine, University of Colorado School of Medicine, Denver, USA. Pat.Knox@UCHSC.edu
PMID