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Medline ® Abstract for Reference 12

of 'Pathophysiology and prediction of chemotherapy-induced nausea and vomiting'

Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs.
Bountra C, Gale JD, Gardner CJ, Jordan CC, Kilpatrick GJ, Twissell DJ, Ward P
Oncology. 1996;53 Suppl 1:102.
The introduction of 5-HT3 antagonists, such as ondansetron, as antiemetic agents has transformed the management of patients receiving chemotherapy or radiation therapy. Studies in animal models with NK1 antagonists suggest that these represent a new class of antiemetic agents having a broader spectrum of activity than 5-HT3 antagonists. Compounds of this class may prove to be more effective in man against delayed emesis induced by cisplatin, post-operative nausea and vomiting and motion sickness. Thus, they have the potential to complement 5-HT3 antagonists and so provide a further advance in the management of nausea and vomiting.
Division of Biology, Glaxo Research and Development Ltd., Ware, Herts., UK.