Polycystic ovary syndrome (PCOS) accounts for the vast majority of anovulatory symptoms and hyperandrogenism in women [1-3]. The diagnosis of PCOS has life-long implications with increased risk for infertility, metabolic syndrome, type 2 diabetes mellitus, and possibly cardiovascular disease and endometrial carcinoma [4,5]. It should be considered in any adolescent girl with hirsutism, persistent acne, menstrual irregularity, or obesity.
The pathophysiology and etiology of PCOS in adolescents will be presented here. Other aspects of PCOS in adolescents are discussed separately:
●(See "Definition, clinical features and differential diagnosis of polycystic ovary syndrome in adolescents".)
●(See "Diagnostic evaluation of polycystic ovary syndrome in adolescents".)
●(See "Treatment of polycystic ovary syndrome in adolescents".)