Medline ® Abstract for Reference 239
of 'Pathogenesis of hepatic fibrosis'
239
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Toll-like receptor 4 and hepatic fibrogenesis.
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Pradere JP, Troeger JS, Dapito DH, Mencin AA, Schwabe RF
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Semin Liver Dis. 2010;30(3):232. Epub 2010 Jul 21.
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.
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Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
PMID