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Pathogenesis of common variable immunodeficiency

Authors
Sam Ahn, MD
Charlotte Cunningham-Rundles, MD, PhD
Section Editor
E Richard Stiehm, MD
Deputy Editor
Anna M Feldweg, MD

INTRODUCTION

Common variable immunodeficiency (CVID) is a heterogeneous immune disorder characterized by recurrent sinopulmonary infections, autoimmune disorders, granulomatous disease, and an enhanced risk of malignancy [1-7].

Definition — CVID is defined by the following:

Markedly reduced serum concentrations of immunoglobulin G (IgG), in combination with low levels of immunoglobulin A (IgA) and/or immunoglobulin M (IgM)

Poor or absent antibody response to infection or immunization, or both

An absence of any other defined immunodeficiency state

              

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Literature review current through: Nov 2016. | This topic last updated: Thu May 26 00:00:00 GMT+00:00 2016.
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References
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