A major public health concern regarding blood products in general and plasma derivatives in particular is the possibility that plasma used for further manufacture and eventual transfusion or administration may be contaminated with one or more viral agents (eg, HIV, HCV, parvovirus) or with other pathogens.
While some have argued that the pathogen inactivation procedures discussed below eliminate concerns about the presence of infectious agents in donor plasma, most authorities agree that adherence to strict standards of donor recruitment and donor screening are still necessary for ensuring the safety of these products. Blood donor screening and testing of blood for pathogens are discussed separately.
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