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Parainfluenza viruses in adults

Author
Michael G Ison, MD, MS
Section Editor
Martin S Hirsch, MD
Deputy Editor
Anna R Thorner, MD

INTRODUCTION

Parainfluenza viruses are important respiratory pathogens in adults and children. Although parainfluenza viruses are commonly recognized as a significant cause of morbidity and mortality in children, their impact in adults is less well characterized [1]. In adults, parainfluenza viruses usually cause mild upper respiratory infections but can lead to life-threatening lower respiratory tract infections, particularly in immunocompromised patients [1,2].

The virology, clinical manifestations, diagnosis, and treatment of parainfluenza viruses in adults will be reviewed here. Infection with parainfluenza viruses in children is discussed separately. (See "Parainfluenza viruses in children".)

VIROLOGY

Parainfluenza viruses (PIVs) are single-stranded, enveloped RNA viruses belonging to the genus Paramyxovirus in the Paramyxoviridae family [3]. This family also includes mumps, measles, respiratory syncytial viruses, human metapneumovirus, and Nipah and Hendra viruses [4-6].

Structure — Parainfluenza virions are pleomorphic, range in diameter from 150 to 200 microns, and contain approximately 15,500 nucleotides [4]. The single strand of negative-sense RNA encodes the following viral proteins: nucleocapsid protein (N), phosphoprotein (P), matrix protein (M), fusion glycoprotein (F), hemagglutinin-neuraminidase glycoprotein (HN), and polymerase (L) (figure 1) [4]. In addition, serotype PIV-3 encodes C, D, and V proteins, PIV-1 encodes a C protein, and PIV-2 encodes a V protein.

The HN and F proteins project through the lipid envelope and form the major antigenic targets for neutralizing antibody [7].

                      

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Literature review current through: Nov 2016. | This topic last updated: Tue Nov 24 00:00:00 GMT+00:00 2015.
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